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The role of systemic immune-inflammation index in predicting lymphovascular space invasion in endometrial cancer patients: A nomogram approach
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Y. Li   , Z. Xie , J. Liu , J. Piao |
| Department 3 of Gynecological Oncology, Jilin Cancer Hospital, Changchun, Jilin, China , 13578945886@163.com |
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Abstract: (45 Views) |
Background: To delve into the association between preoperative immune-related markers and lymphovascular space invasion (LVSI) in patients with endometrial cancer (EC). Materials and Methods: According to the 7:3 allocation, 411 EC patients were analyzed. Clinical and pathological data were collected, and imaging histologic features were extracted from contrast-enhanced T1-weighted imaging (CE-T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps, the related factors affecting LVSI were analyzed. Subsequently, a backward step-wise selection approach was adopted to select the most relevant variables for incorporation into the nomogram. Results: In the training cohort, independent predictors for LVSI were identified as systemic immune-inflammation index (SII), depth of myometrial invasion (MI), and carbohydrate antigen 125 (CA125) levels. The nomogram was used to predict the probability of LVSI, and the area under the ROC curve was 0.7813. Conclusion: LVSI positivity in EC patients is strongly associated with elevated SII, MI≥1/2, and high CA125 levels. The SII-based nomogram provides a reliable tool for predicting LVSI status in EC patients. |
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| Keywords: Endometrial cancer, nomogram, magnetic resonance imaging, diagnosis, risk modeling. |
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Full-Text [PDF 979 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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