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Value of quantitative MRI combined with blood CTC in predicting the prognosis of neoadjuvant chemotherapy for breast cancer
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W. Junwu   , L. Yi , T. Lidong , L. Qichao |
| Department of Breast Surgery, Chengdu Xinhua Hospital, Chengdu, Sichuan, China , wangjunwudf@163.com |
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Abstract: (55 Views) |
Background: To analyze the value of quantitative parameters of magnetic resonance imaging (MRI) combined with circulating tumor cells (CTC) in predicting the prognosis of neoadjuvant chemotherapy (NAC) for breast cancer. Materials and Methods: Ninety-eight breast cancer patients treated with NAC from January 2022 to January 2024 at our institution were collected. Pathological complete remission (pCR) was evaluated 2 weeks after the end of NAC. According to pCR, the patients were divided into pCR group (n=34) and non-pCR group (n=64). The volume transfer constant (Ktrans), extravascular extracellular space volume ratio (Ve), rate constant (Kep), and positive rate of CTC were compared between the two groups before and after treatment. The area under the receiver operating characteristic (ROC) curve (AUC) was used to express the prognostic value. Results: Among the 98 patients, 34 patients achieved pCR, with a rate of 34.69%. After treatment, Ktrans, Kep, and positive rate of CTC were lower than those before treatment (P<0.05), and were lower in the pCR group than in the non-pCR group (P<0.05). Ktrans, Kep, and positive rate of CTC were positively correlated with TNM staging (P<0.05). The AUCs of Ktrans, Kep, and positive rate of CTC joint prediction for predicting pCR after NAC for breast cancer was 0.847, which was larger than separate prediction. The sensitivity and specificity of joint prediction were 67.65% and 90.38%. Conclusion: The quantitative MRI indexes combined with blood CTC can effectively predict NAC prognosis in breast cancer patients. |
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| Keywords: Breast neoplasms, neoadjuvant therapy, magnetic resonance imaging, circulating tumor cell. |
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Full-Text [PDF 967 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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