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Sonodynamic therapy of breast cancer cells using 1 MHz ultrasound: impact of gold nanoparticles
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J. Ordoni   , M. Mokhtari-Dizaji , H. Mozdarani , S.R. Mahdavi |
| Department, of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , mokhtarm@modares.ac.ir |
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Abstract: (21 Views) |
Background: Sonodynamic therapy (SDT) has emerged as a promising adjunctive treatment in cancer therapy, leveraging ultrasound and sensitizers to generate reactive oxygen species and induce tumor cell death. This study evaluated the efficacy of SDT with and without gold nanoparticles (NPs) as sensitizers on two breast cancer cell lines. Materials and Methods: Using gold NPs, MCF7 and MDA-MB-231 breast cancer cells were incubated and subjected to ultrasound irradiation at 1 MHz. In the case of treatment, ultrasound alone and ultrasound combined with NPs were taken into consideration. Cell viability was measured 48 hours post-treatment using the MTT assay. Results: There were significant differences in cell viability between the treated and control groups. For MCF7 cells, a 1-minute continuous ultrasound reduced survival to 60% (p<0.05), and MDA-MB-231 cells showed 65% viability under the same conditions (p<0.05). Therefore, enhanced therapeutic effects were detected by the use of gold NPs. Conclusion: SDT, combined with gold NPs, reduced breast cancer cell viability, particularly. This approach could potentially offer a safer alternative to conventional therapies by minimizing side effects while maintaining therapeutic efficacy. |
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| Keywords: Sonodynamic therapy, breast neoplasms, gold NPs, ultrasonics, cell line. |
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Full-Text [PDF 1033 kb]
(13 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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