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Correlation between clinical characteristics of chronic obstructive pulmonary disease in patients with lung cancer undergoing radiotherapy and the expression of serum chemokines CCL18 and CCL21
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Y. Guo   , J. An |
| Department of Oncology, Sengong Hospital of Shaanxi Province, Xi’an, Shaanxi, China |
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Abstract: (33 Views) |
Background: Chronic obstructive pulmonary disease (COPD) frequently coexists with lung cancer (LC), and radiotherapy is a key treatment option in patients with limited pulmonary reserve. This study aimed to investigate clinical characteristics, pulmonary function, and serum chemokine levels (CCL18 and CCL21) in COPD patients with LC undergoing radiotherapy. Materials and Methods: This retrospective study included 90 COPD patients with LC treated with radiotherapy (experimental group) and 85 patients with COPD alone (control group). Radiotherapy was delivered using intensity-modulated radiotherapy (IMRT), three-dimensional conformal radiotherapy (3D-CRT), or stereotactic body radiotherapy (SBRT), based on computed tomography–guided planning and standard fractionation protocols. Clinical characteristics, smoking index, and pulmonary function parameters were recorded. Peripheral venous blood samples were collected 2–4 weeks after completion of radiotherapy, and serum CCL18 and CCL21 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: Compared with the control group, patients in the experimental group had significantly higher rates of weight loss, hemoptysis, chest pain, and pleural effusion (P<0.05). Total lung capacity (TLC) and diffusing capacity for carbon monoxide (DLCO) were significantly reduced, whereas FEV1/FVC and FEV1% predicted showed no significant differences. Serum CCL18 and CCL21 levels were significantly elevated in the experimental group (P<0.05) and were positively correlated with heavy smoking and thoracic symptoms, but negatively correlated with TLC and DLCO. Conclusion: Serum CCL18 and CCL21 levels are elevated in COPD patients with LC undergoing radiotherapy and are associated with increased symptom burden and impaired lung function. These chemokines may serve as potential biomarkers of radiotherapy-related inflammatory activity and lung injury. |
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| Keywords: COPD, lung cancer, radiotherapy, CCL18, CCL21, clinical characteristics, lung function, smoking index. |
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Full-Text [PDF 1472 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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