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Experimental forensic aspects of ionizing radiation: A postmortem study on supra-lethal dose irradiated rats
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W.T. Tawfik   , Z.S. Said , M.R. Mohammed , M.M. Ahmed , S.A. Montaser |
| Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egypt, Egyptian Atomic Energy Authority, Nasr City, Egypt , mahmoud_70mohameds@yahoo.com |
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Abstract: (20 Views) |
Background: Forensic science rarely deals with radiation accidents and radiotherapy doses, which may lead to death in the scientific and medical fields. These are the consequences and causes of death because of supra-lethal dose (20 Gy) of radiation exposure and detecting the times of death and monitoring the postmortem changes in the different groups. Materials and Methods: The experiment was designed using four groups of Sprague-Dawley albino rats (6 male rats each). Rats were exposed to supra-lethal (20 Gy) with a dose rate (0.717 KGy/h) gamma radiation (Cobalt-60 γ-radiation).The postmortem study was conducted in four time intervals (0, 6, 8 and 20 hours). Comparison was done for verification of the two goals. The first one is to monitor the incidence of death and the second is to investigate the postmortem changes over time between groups. The study included cytogenetics, biochemical and histopathology analysis. Results: showed a non-traditional interpretation of death resulting from supra-lethal dose radiation exposure. Moreover, the study scrutinized death timing via the different groups and presenting a comparison between the physiological changes that occurred over time. Conclusion: The main unique causes of death after supra-lethal dose irradiation are devastation of the bone marrow and collapse of its vital function, microbiome invasion, andloss of communication pathways between cells and each other and between cells and organs, then a multi-organ succession failure. |
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| Keywords: Supra-lethal dose radiation, postmortem changes, cytogenetic analysis, biochemical estimation, liver and brain histopathology. |
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Full-Text [PDF 1229 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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