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Treatment of high-altitude polycythemia with radiopharmaceutical platform of poly (lactic-co-glycolic acid) nanoparticles loaded with hydroxyurea
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J. Nie   , D. Wang , M.J. Li |
| School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China , fcmlnj@163.com |
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Abstract: (16 Views) |
Background: High Altitude Polycythemia (HAPC) is a chronic hypoxia-related disorder characterized by excessive erythrocytosis, hypercoagulability, and organ dysfunction. Hydroxyurea (HU) is used clinically but is limited by systemic toxicity and suboptimal targeting. This study aimed to evaluate the therapeutic efficacy and biodistribution of a radiopharmaceutical platform based on poly(lactic-co-glycolic acid) nanoparticles loaded with hydroxyurea (HU-PLGA-NPs) in an experimental HAPC model. Materials and Methods: Sixty male Sprague–Dawley rats with hypobaric hypoxia-induced HAPC were randomized into three groups: HU-PLGA-NPs, conventional HU, and supportive treatment. Nanoparticles were radiolabeled with technetium-99m to assess in vivo biodistribution using SPECT/CT imaging. Hematological parameters, coagulation indices, hemorheology, immune markers, bone marrow apoptosis, and liver and renal function were evaluated over 12 weeks. Results: HU-PLGA-NP treatment significantly reduced hemoglobin, hematocrit, blood viscosity, and coagulation abnormalities compared with conventional HU and supportive therapy (p<0.05). Imaging and biodistribution studies demonstrated preferential accumulation in bone marrow and spleen. Improved immune parameters and reduced hepatic and renal toxicity were observed in the nanoparticle group. Conclusions: The HU-PLGA-NP radiopharmaceutical platform enhances therapeutic efficacy and targeting while reducing systemic toxicity in HAPC, representing a promising strategy for precision treatment. |
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| Keywords: Hydroxyurea, PLGA nanoparticles, radiopharmaceutical platform, technetium-99m, high altitude polycythemia, biodistribution, liver function, coagulation indices. |
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Full-Text [PDF 1117 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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